منابع مشابه
Human Immunodeficiencies Related to Defective APC/T Cell Interaction
The primary event for initiating adaptive immune responses is the encounter between T lymphocytes and antigen presenting cells (APCs) in the T cell area of secondary lymphoid organs and the formation of highly organized intercellular junctions referred to as immune synapses (IS). In vivo live-cell imaging of APC-T cell interactions combined to functional studies unveiled that T cell fate is dic...
متن کاملHuman Dendritic Cell
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متن کاملHuman dendritic cell subsets
Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allow...
متن کاملGene therapy of primary T cell immunodeficiencies.
Gene therapy of severe combined immunodeficiencies has been proven to be effective to provide sustained correction of the T cell immunodeficiencies. This has been achieved for 2 forms of SCID, i.e SCID-X1 (γc deficiency) and adenosine deaminase deficiency. Occurrence of gene toxicity generated by integration of first generation retroviral vectors, as observed in the SCID-X1 trials has led to re...
متن کاملHuman Dendritic Cell Differentiation Pathway
The most effective antigen-presenting cells for T lymphocytes are dendritic cells (DCs), the differentiation pathway of which, however, is incompletely characterized. We examined here how DCs differentiated from human cord blood CD34+ progenitor cells cultured with granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-a, and stem cell factor. After 5 days, 2 of 3 nonadherent c...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2019
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2018.02.020